New Treatment Options

PROVENGE® Treatment

Hunterdon Hematology Oncology is a Certified PROVENGE® Treatment Center. PROVENGE (sipuleucel-T) is the only FDA-approved treatment for men with advanced prostate cancer that is clinically proven to extend life in certain men by reprogramming their own immune system to target and attack prostate cancer.

What is PROVENGE®?

PROVENGE® (sipuleucel-T) is approved by the FDA as an autologous cellular immunotherapy for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer.

PROVENGE is a treatment option for men with asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer.

PROVENGE is designed to use your immune system to fight prostate cancer. Your immune system is made up of immune cells found in your blood. These cells work as your body’s natural defense against all types of illness, including prostate cancer.

Your personalized dose of PROVENGE consists of your own immune cells that have been activated with a recombinant antigen to seek and attack prostate cancer cells. By stimulating the natural ability of immune cells already in your blood, PROVENGE may help you live longer.

How Is Provenge Different?

Even though your immune system works to defend you against infection and disease, sometimes cancer cells can “hide” from your immune system.

PROVENGE is the only FDA-approved prostate cancer immunotherapy. It is the first in a new class of therapy to use this approach.

What Are the Benefits I Might Receive From PROVENGE?

PROVENGE is an exciting innovation in the treatment of advanced prostate cancer.

PROVENGE may help you live longer

• In a clinical study, PROVENGE reduced the risk of death in men by 22.5%
• Treatment is complete after 3 infusions, given approximately 2 weeks apart
• The most common side effects are primarily mild or moderate
• These side effects include chills, fatigue, fever, back pain, nausea, joint ache, and headache
• In one study of PROVENGE, less than 1.5% of patients in the PROVENGE group had to stop treatment due to side effects.

Your Prostate-Specific Antigen Levels

The prostate-specific antigen (PSA) test is often used to monitor progression of prostate cancer and how effective your treatment may be at controlling it. It is important to note that changes in PSA levels may not be a good sign of whether you are benefitting from treatment with PROVENGE. Even if your PSA levels don’t change, PROVENGE may still be working.

Indication and Important Safety Information

Indication

PROVENGE® (sipuleucel-T) is approved by the FDA as an autologous cellular immunotherapy for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer.

Important Safety Information

PROVENGE is made from your own immune cells. Your cells will be collected at a cell collection center approximately 3 days before each scheduled infusion of PROVENGE. There can be risks associated with the cell collection process, which you should discuss with your doctor before deciding to begin treatment with PROVENGE.

PROVENGE can cause serious reactions. In controlled clinical trials for the treatment of prostate cancer, serious reactions reported in patients in the PROVENGE group included reactions resulting from the infusion of the drug, which occurred within 1 day of infusion, and strokes. Severe infusion reactions included chills, fever, fatigue, weakness, breathing problems (shortness of breath, decreased oxygen level, and wheezing), dizziness, headache, high blood pressure, muscle ache, nausea, and vomiting. Tell your doctor right away if you have breathing problems, chest pains, racing heart or irregular heartbeats, dizziness, nausea, or vomiting after getting PROVENGE because any of these may be signs of heart or lung problems.

The most common side effects reported with PROVENGE were chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor.

• Tell your doctor about all your medical problems including heart problems, lung problems or a history of stroke.
• Tell your doctor right away if you get a fever over 100°F, or redness at the cell collection or infusion sites, because any of these may be signs of infection.
• Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements.
• Tell your doctor about any side effect that concerns you or does not go away.

For more information link to www. PROVENGE.com, please see the Full Prescribing Information or call Dendreon ON Call at 1-877-336-3736.